pipx pyenv python How to use pipx with pyenv 👨🏻💻 TL;DR In my case with fish I added this line to my config.fish: set -gx PIPX_DEFAULT_PYTHON "$HOME/.pyenv/versions/3.8.5/bin/python" It's roughly the bash equivalent for export PIPX_DEFAULT_PYTHON="$HOME/.pyenv/versions/3.8.5/bin/